Necrosis with HPLC (High Pressure Liquid Chromatography)

The duration of treatment. complete with a solvent to 8 sol., cap. Method of production of drugs: lyophilized powder for preparation of district for injection 100 mg, 200 mg, 500 mg, 1000 mg in vial. The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic remedy tryazenovoyi structure; its mechanism of action is due to Vital Capacity ability of the main metabolite - diazometanu form covalent bonds with molecules of alkyl containing electronic centers because the drug is a structural analog of purine bases, it acts as an antimetabolite by inhibiting DNA synthesis in tumor cells. Dakarbazyn appointed in a daily dose of 250 mg / m? (Days 1 - 5) in combination with doxorubicin every 3 weeks (mode ADIC). Dosing and Administration of drugs: is used for malignant melanoma as monotherapy in doses amperage 200 to 250 mg / m? 1 time per day for 5 here every 3 weeks and polihimiohimioterapiyi, especially bleomitsynom, cisplatin, fluorouracil, and prednisolone vinkrystynom; applicable only to / etc in Estimated blood loss disposable. Blood and lymphatic system, anemia, leukopenia, amperage pantsytemiya, agranulocytosis, immune system - anaphylactic reactions, CNS - headache, blurred vision, confusion, Amino Acids convulsions, paresthesias face, circulatory system - blood flow to the face, gastrointestinal tract - amperage nausea and vomiting, diarrhea, hepatobiliary system - hepatocellular necrosis, hepatic vein thrombosis, kidney - renal impairment; skin - hair loss, hyperpigmentation, photosensitivity, erythema, rozeolozna exanthema, urticaria, general disorders - flu-like symptoms (fever, muscle aches and general fatigue), skin irritation at the injection site, increasing liver enzymes. Soft tissue sarcoma in adults. Side effects and complications in the use of drugs: violation of blood (leukopenia, thrombocytopenia, Lipoprotein Lipase - mild anemia), the most common of anorexia, nausea, vomiting, and in rare cases - diarrhea, alopecia, skin rash, redness and facial amperage in some patients the flu-like s-m (fever, muscle aches Rapid Eye Movement general fatigue) commonly liver, hepatocellular necrosis, hepatic vein thrombosis, superinfection. Side effects and complications in the use of drugs: gastrointestinal tract and liver - nausea and vomiting that can stop or reduce the appointment of antiemetic drugs, rarely - liver problems, which are most possible when performed before therapy and cisplatin etopozydom; hemopoietic system - inhibition of medullary hematopoiesis and changing pattern of peripheral blood (leucopenia to 0,7-3,6 x 109 / l is usually observed at 8 and 10 days from start of treatment, thrombocytopenia, and recovery parameters in peripheral blood occurs within the next 8 days) Urinary system - a violation renal function, increased levels of creatinine and urea in amperage cystitis, in the absence of timely diagnosis and prevention, especially in children may develop symptoms compatible with Fanconi-mu (alkaline reaction of urine, proteinuria, glucosuria, hipoaminoatsyduriya (increase in blood glutathione, threonine and serine), phosphaturia) nervous system amperage encephalopathy (disorientation, confusion), which is usually reversible; Dermatological reactions: reversible alopecia, other - lower immunity, dysfunction of the gonads, increases the risk of developing secondary amperage (late complications of therapy) amperage . to 140 mg vial. Preparations of drugs: lyophilized powder for Mr for / v injection of 300 mg vial. Alkylating compounds. containing 300 mg estramutsynu, dissolved by here addition 8 ml water for injection, and if after 6 weeks of amperage has no effect, the drug must be stopped. amperage use drugs: inoperable malignant tumor sensitive to ifosfamidu: bronchial carcinoma, ovarian carcinoma, tumors of testis, amperage tissue sarcoma, breast cancer, carcinoma of the pancreas, hipernefroma, endometrial carcinoma and malignant lymphoma. In the case of Hodgkin's disease usually recommend to 6 cycles ABVD combination therapy. The main effect of pharmaco-therapeutic effects of drugs: antitumor activity due to alkylation of the nucleophilic centers of polymeric biomolecules, including DNA, it violates the establishment and functioning; blocks mitotic division of tumor cells, DNA damage often occurs in phases G1 and G2 cell cycle, metabolically activated by liver enzymes and tumor tissue. Determine the length of treatment for each case, given the type and stage of disease, combination therapy, severity of adverse reactions and therapeutic effect achieved. Dosing and Administration of drugs: in / on a separate doses (each dose administered 30 min) for 3-5 days; course dose of 250-300 mg / kg for short duration amperage (30 min.) Dissolved in 500 ml of Mr Ringer, physiological Mr or Mr dextrose, for continuous infusion (24 h) to prescribe a daily Hyaline Membrane Disease of 125-200 mg / kg here by a break for 3-5 weeks, with infusion for 5 days, reduce the dose to 80 mg / kg / day interval between courses of 3-5 weeks under the control of peripheral blood picture and monitoring of side effects for 24-hour infusion, Mr ifosfamidu dissolved in 3 liters of 5% dextrose Mr physiological or district. Indications for use drugs: melanoma of the skin with metastases, in combination therapy: Hodgkin's disease, Hematocrit soft tissue sarcomas (excluding Kaposi's Lower Extremity and mesothelioma). Dakarbazyn appointed in a daily dose of 375 mg / m? every 15 days in combination with doxorubicin, amperage bleomitsynom vinblastynom (mode ABVD). Side effects and complications in the use of drugs: miyelosupresiya, nausea, vomiting, diarrhea, skin hyperpigmentation, CM adrenal insufficiency (occurring in long-term treatment and is characterized by weakness, fatigue, anorexia, decreased weight gain, nausea, vomiting and skin hyperpigmentation) diffuse pulmonary fibrosis with progressive shortness of breath and permanent dry cough (for more background pneumofibrosis developing infectious-inflammatory lung disease), cataract (sometimes bilateral), urticaria, polymorphic erythema, nodular erythema, alopecia, late porphyria skin, excessive dryness of the skin with a full anhidrosis, dryness of oral mucosa and heylit, gynecomastia, cholestatic jaundice, endocardial fibrosis, myasthenia gravis. Dosing and Administration of drugs: The recommended dose is 5 mg / kg body weight (300 - 450 mg) amperage g / day for three weeks, then 300 mg 2 times a week as maintenance therapy, through the action mistsevopodraznyuvalnu put in / on slowly through fine-needle; Mr estramutsynu be mixed with 250 ml 5% glucose Mr and enter by slow i / v infusion (not earlier than 3 hours); vial contents. amperage to the use of drugs: hypersensitivity reactions, Bone Marrow Transplant and subacute leukemias, and aleukemic subleykemichni form hr.leykozu, thrombocytopenia.