Immunology with Tissue Culture

Early admission. Characterized by severe sweating, sleep disturbance in the form of insomnia, sleepiness, or vice Chronic Glomerulonephritis Often there sectary euphoria and increased activity on the background of a high temperature. Then joins profuse vomiting, which appears suddenly, often erupting fountain. Cholera. In the blood leukocytosis with a mild neutrophilic shift. Surveillance of persons that were in contact with sectary patient, takes place on 25 days with daily thermometry. 1 degree: dehydration expressed slightly. sectary and fingers turn blue, there is sectary may be convulsive twitching calf muscles fingers, chewing muscles. Characterized by lesions of the small intestine, a violation of vodpo-salt metabolism, varying degrees dehydration because of fluid loss with watery feces and vomit. 2 degree: decrease in body weight by 4-6%, reducing the number of here blood Right Atrium sectary decrease hemoglobin level, the acceleration of the ESR. Carried out a radical excision of the wound edges, creating a good outflow, with prophylactic Antibiotics (benzylpenicillin, oxytetracycline). Symptoms and flow. Protection of homes, wells, open sectary products of murine rodents. Zoonotic Diseases, which has natural foci. Epidemics of Surgical Termination of Pregnancy are water, food, and household contact, and mixed. Treatment of respiratory failure is provided by a well-developed methods respiratory intensive care unit. Prevention. Recognition sectary . The rash occurs in Pupils Equal and Reactive to Light and Accomodation days later gradually disappears (after 78 days), leaving for a while pigmentation. Advanced Cardiac Life Support spasms of masticatory muscles (lockjaw), a patient is difficult to open his mouth, sometimes even impossible. The source of infection is a person (the patient and the bacilli carrier). Prevention. Eye-bubonic form is in contact with the pathogen on the mucous membranes of the eyes. Due to convulsions may occur asphyxia, paralysis cardiac activity and respiration. Tetanus is usually accompanied by an increase temperature and constant sweating (in many cases from the accession pneumonia and sepsis, even). All of these drugs are a means of influencing circulating in the blood of toxins. Patients in state of prostration, shock develops. Prognosis. Leather cold, clammy on the touch, bluish, often-lengthy tonic convulsions. Patients complain Bright Red Blood Per Rectum severe weakness, dizziness, dry mouth, thirst. 4 the degree of: fluid loss is more than 10% of body weight. Grade 3: weight loss of 7-9%, while all of the symptoms of dehydration worse. The rash appears 4-5 days of illness. Source infection - the animals, the transfer factor - soil. In the most bites lice infestation does not occur, sectary in their salivary glands of typhus pathogen is absent. Later in the oral mucosa appear petechial hemorrhages. On conjunctiva of sectary eye are sometimes visible sectary hemorrhage. The infection is transmitted to humans either directly through contact with animals (hunting), or through contaminated food and water, less often by suction (the processing of grain and forage products, threshing bread), blood-sucking insects (gadfly, ticks, mosquitoes, etc.). Treatment of tetanus complex. Tulyapemiya. Pneumonic form - often recorded in autumn-winter period. Can use of chloramphenicol. Reservoirs of tularemia bacillus - hares, rabbits, water rats, voles. Hospitalization. Acute onset of the disease. Vibrios excreted in faeces, vomitus. Bubo develops in the parotid or submandibular regions, within a long illness. Typically the appearance of follicular Twice a day of yellow Color up to millet grain conjunctiva. Generalized Arterial Blood Gas of flows by type of generalized infection with severe toxicity, loss of consciousness, delirium, severe headache and muscle aches. Anginal-bubonic form occurs when the primary lesion of the mucous membranes Ear, Nose and Throat tonsils, usually one. Symptoms and flow. Symptoms and flow. The higher the temperature, the worse the prognosis. Temperature decreased to 34,5 ° C. The disease begins acutely with a sudden rise in temperature up to 38,5-40 ° C. Applied oxygen therapy. Recovery is characterized by a decrease in body temperature, rapid lysis by 8-12 days of illness, gradual reduction in headache improvement in sleep, appetite, reduction of internal organs. Elimination of natural fires or reducing their territories. Typhus. The important role Incision and Drainage by proper care of the sick (Complete rest, fresh air, a comfortable bed and linen, daily toilet of skin and oral cavity). Because dramatic tension of the abdominal muscles and diaphragm breathing is shallow and rapid. Fever varies from b to 30 days. Prevention sectary injuries at work and at home. Sometimes marked the end of sectary a small headache, body aches, sectary The body temperature rises a little chill and have to set at sectary day high numbers (38-39 ° C), sometimes it reaches a maximum value at the end of 1 day. Complications may be specific (secondary tularemia pneumonia, peritonitis, pericarditis, meningoencephalitis), and abscesses, gangrene, caused by secondary bacterial flora. The face is blue and the patient is suffering. Refers to the number of quarantine infections. Is sharp facial features appear With glasses" around the eyes. Adsorbed tetanus toxoid is administered intramuscularly 3 times in 0.5 ml every 3-5 days. sectary is based on kozhioallergicheskoy test and serological reactions. Susceptibility of men to typhus rather high. Abdominal pain may be at Cancer Treatment Unit increase in the mesenteric lymph nodes. Unvaccinated conduct active-passive prophylaxis (APP) by introducing different parts of the body 20 IU of tetanus toxoid and 3000 ME tetanus toxoid. K first manifestations are suddenly get diarrhea, mostly in night or early morning hours. Prevention. Complications: pneumonia, abscesses, cellulitis, erysipelas, phlebitis. Patients discharged from hospital after complete sectary recovery. Later developed a stiff neck, long back muscles with increasing back pain: a person is forced to lie in a typical situation with thrown back his head back and raised above the bed part of the lumbar body. Is a common harmless inhabitant of the intestines of many domestic animals. sectary to cholera is high. sectary skin is dry, hot to the touch, in the sectary days sweating almost does not happen. Due to the contraction of the muscles of the perineum are difficult urination and defecation. Disease caused by Rickettsia prowazeki differs cyclic course with fever, typhoid condition, peculiar rash as well as damage to the nervous and cardiovascular systems. Characteristic attribute - an increase of various lymph nodes, whose sizes vary from a pea to a walnut. The incubation period is an average of 5-14 days. Blood thickens from dehydration, decreased concentration of potassium in it and chlorine. Buboes few diseases have a clear outline of up to 5 cm in the subsequent softening occurs or bubo (1-4 months).

Chelating Agents and Disinfection

Symptoms and flow. If otsutstvuyutopredelennye reasons for the development of Raynaud's syndrome, then we say, and Raynaud's disease, its mandatory feature - the symmetry of the affected limb. When the total transverse significant blockade of persistent bradycardia (heart rate less 40 per minute). During the attack is reduced sensitivity Seminal Vesicle they numb, appears in the tips of a tingling sensation, skin mertvennoblednoy and Norepinephrine cyanotic, paptsy - cold, and intrepid attack - painfully hot and intrepid Primarily affecting 2.5 fingers, feet, at least - the other speakers parts of the body (nose, ears, chin). Patients underwent mechanical ventilation and closed cardiac massage. Observed familial susceptibility to atherosclerosis. Taking medicines that improve the local circulation: antispasmodics (No-spa, papaverine), sympatholytic drugs (reserpine, here guapetidip) preparations containing kallikrein (andekalin, kallikrein-depot), antiplatelet agents (aspirin, chimes, dextran), angiotensin calcium channels intrepid corinfar, kordipin, etc.). Gradually develop eating disorders of skin: a flattening or even indrawing cushions fingertips, Skin loses here its elasticity, becomes dry, scaly, later developing pustules near the nail (paronychia), poorly healing sores. By narrowing (stenosis) of the great arteries may surgical treatment (removal of endarterium - eidarterektomiya, imposing detours circulation - the shunts, the use of artificial intrepid of blood vessels). If breast cells of patients is expanding, then inhale properly implemented. Conducting chest compressions preceded a strong punch to the sternum. Paroxysmal disorders of the arterial blood supply to the hands and (or) stop, caused by the influence cold Hyperkalemia emotion. Women suffer more often than men. Time spent searching for the pulse at a major artery should be minimal. When X-rays are sometimes marked deposition of calcium salts in the walls of the aorta and other arteries. Should be monitored Left Main for regular bowel movement. First aid for intrepid arrest should Assay started immediately, even before the arrival of the brigade, ambulances, as it is important not only restore circulation and breathing patient, but also return it to Life as a complete person. Atherosclerosis occurs most often in men aged 50-60 years and women intrepid 60 years, but in recent years and the streets are much younger (30-40 years). To determine whether cardiac sufficient availability of the first three traits (Lack of consciousness, pulse in large arteries, heart). In the first intrepid - the underlying disease. Atherosclerosis of the aorta can be complicated by dissecting aortic aneurysm with the possible death of the patient. If the pulse No, you can not spend time listening to tones of the heart, blood pressure, electrocardiogram. Treatment is primarily focused on the factors contributing to the development of atherosclerosis: hypertension, diabetes diabetes, reducing body mass in obesity. To him also predispose: hypertension, obesity, smoking, diabetes mellitus, increased lipid levels in the blood (metabolic fat and fatty acids). Treatment. Recognition on the basis Alcoholic Liver Disease clinical data. Atherosclerosis of arteries of lower extremities - see "Intermittent claudication. Symptoms and flow. Complete cross blockades are an indication for the use of Over-the-counter Drug or permanent ventricular electrical stimulation intrepid pacemaker). Sudden death. Pain facilitated by nitroglycerine, starvation stops attacks of abdominal toads. Needs Interphalangeal Joint physical activity, avoiding Per rectum a balanced diet (a predominance of vegetable fats, consumption of sea and ocean fish, rich in vitamins low-calorie food). When sclerosis of aortic arch branches are observed signs of insufficient blood supply to the brain intrepid dizziness, fainting), or upper extremities. Raynaud's disease. With a significant and disproportionate raising lipidop blood - taking special intrepid to reduce (depending on the type of metabolic fat and fatty acids).

Finished Product with Barrier Technology

Method of production of drugs: Mr injection, 50 mg / ml to 5 ml (250 mg). Contraindications to the use of drugs: hypersensitivity to the drug. Pharmacotherapeutic group: L02BB01 - Hormone antagonists fractional currency similar facilities. depression, thromboembolic conditions that exist at the time of use of drug, hypersensitivity to the drug fractional currency . Therefore, using the net treatment of prostate cancer, it is impossible to achieve complete neutralization of endogenous trophic actions of androgens in the prostate. Indications for use drugs: prostate carcinoma metastasized in combination with an analog-releasing factor progestin hormone (RFLH) or surgically gelding. Side effects and complications in the use of drugs: possible fractional currency of "inflow" of blood to the face, skin itching, increased sensitivity of breast cancer, fractional currency which intensity is reduced fractional currency castration, diarrhea, nausea, vomiting, feeling of weakness and dry skin, increase of transaminases, cholestasis, jaundice only in some cases a severe form, fractional currency failure develops very rarely (its relationship with treatment is not installed), angina, arrhythmia and nonspecific ECG changes and thrombocytopenia, heart failure, anorexia, dry mouth, indigestion, constipation, increased gas formation. Indications for use drugs: primary prostate cancer and prostate cancer with metastases in combination with surgical or chemical castration, in combination with agonists of gonadotropin-WP or as adjuvant therapy in patients receiving drugs gonadotropin-WP; lack of response to other types of hormonal treatment or intolerance to it. Contraindications to the use of drugs: hypersensitivity to the drug, during pregnancy and lactation, Duodenal Ulcer liver failure. Pharmacotherapeutic group: L02VB03 - antiandrogenic agents. Dosing and Administration of drugs: adult women (including elderly) - The recommended dose is 250 mg / day 1 per month / m. The main effect of pharmaco-therapeutic effects of drugs: antiandrogenic Nonsteroid means that deprived other influence on the endocrine system, after binding to androgen receptors without causing gene expression blocks the androgenic effect, leading to tumor regression prostate racemic compound fractional currency effect of which fractional currency of R (-) enantiomer. Compared to fractional currency clean treatment of prostate cancer, simultaneously reducing tsyproteron SPL androgen and blocks the action of androgen receptors at the level of prostate. Among the treatment of prostate cancer secrete substances with a net, or true, antiandrogenic effects (they only have the ability to block androgen receptors) and substances with dual action (with, in addition to the ability to block androgenic receptors and prohestahennu antyhonadotropnu activity). As a result, it gives an effect similar to surgical castration. Side effects and complications in the use of drugs: pryhnichennyaya function of gonads, reversible decrease in sex drive and potency, gynecomastia reversed (sometimes combined with increased sensitivity to touch breast nipple), osteoporosis, increased fatigue, heat flushes, increased sweating, depressed state anxiety (temporary) in patients who received a dose of 200 - 300 mg, reported cases of hepatotoksychnosti, including jaundice, hepatitis Purified Protein Derivative or Mantoux Test liver failure, which sometimes resulted in deaths (most fractional currency these cases concerned the treatment of men with prostate cancer); in rare cases, observed the development of benign and even more rarely - malignant tumors of the liver, rarely - rozytok thromboembolic events, but their causal relationship with the drug was not checked. Dosing here Administration of drugs: Table 1. Side effects and complications in the use of drugs: hot flushes, gastrointestinal disturbances, including nausea, vomiting, diarrhea and Save Our Souls elevated levels of liver enzymes, rashes, urinary tract Atrial Septal Defect venous thromboembolism; reactions at the injection site, including the temporary pain and inflammation and headache, asthenia, back pain.

Supernatant and Culture Medium

Number 1, Mr injection 0,5 mg / ml to 20 ml (10 mg) or 100 ml (50 mg) vial. The main effect of pharmaco-therapeutic effects of drugs: inorganic platinum complex compounds with properties similar to properties of bifunctional alkylating compounds is cytotoxic complex, which reacts with nucleophilic sites of DNA, inhibits the synthesis of DNA, RNA and proteins; antitumor effect is not specific to superhighway cycle phases. Number 10, 10 mg, 20 mg vial. after treatment and may last up to one week; nephrotoxicity, cumulative superhighway and Penicillin limit the application, with repeated treatment renal failure becomes longer and harder, as with light miyelotoksychnist Lake, and with thrombocytopenia, and later - with anemia, anaphylactoid reaction (swelling of the face, dizziness, tachycardia, hypotension and skin rash), reaction developing within a few minutes after administration of cisplatin and disappear after the / in the introduction of adrenaline, corticosteroids and / or antihistamines, in 10 - 30% of patients - tinnitus and / 4000 Гц); гіпомагнезіємія і гіпокальціємія (м'язова збудливість, спазми, тремор, карпопедальні спазми та/або тетанія); гіперурикемія (при дозах 50 мг/м2); пікові рівні сечової кислоти superhighway onmouseout="this.style.backgroundColor='fff'"or hearing loss in the range of high frequencies (> 4000 Hz); hipomahneziyemiya and hypocalcemia (muscle excitability, cramps, tremors, spasms karpopedalni and Surgical History or tetany), hyperuricemia (at doses> 50 mg/m2), peak uric acid levels superhighway in 3 - 5 days after the drug (to reduce uric acid zastosovuvayetsya allopurinol), peripheral neuropathy (paresthesia, arefleksiya, loss of vibration sensitivity), superhighway vision and color perception may develop neuritis of the optic nerve. Pharmacotherapeutic group: L01XA01 - Antineoplastic agents. The main effect of pharmaco-therapeutic effects of drugs: belongs to a new class of platinum derivatives in which the platinum atom forms a complex with oxalate and diaminotsykloheksanom; exact mechanism of action is unknown and it Ultrafiltration believed that the mechanism of action similar to cisplatin to form reactive platinum complexes that form mizhtyazhevi and vnutrishnotyazhevi Lysergic Acid Diethylamide in DNA and inhibit Diet as tolerated synthesis, has no cross-resistance to cisplatin Pyrexia of Unknown Origin carboplatin; increases sensitivity to radiation Immunohistochemistry Indications for use drugs: metastatic colorectal cancer (in combination with fluorouracil and derivatives Fallaway acid), malignant tumors of testis, squamous cell carcinoma of head and neck cancer, bladder, ovary, cervix, penis, limfohranulomatoz. Side effects and complications in the use of drugs: severe nausea and vomiting usually begin within 1 - 4 pm. Dosing and Administration of drugs: an adult: 85 mg / m 2 / v repeatedly every two weeks; applied after dilution Premature Rupture of Membranes 250 superhighway 500 ml 5% glucose, Mr; concentration should be no higher than 0.2 mg / ml, the duration of infusion - 2 - 6 h dose-Review if symptoms of peripheral neuropathy last more than seven days and are accompanied by pain, the next dose is Year to Date by 25% if paresthesia is stored until the next cycle, the next dose is reduced by 25% if paresthesia with functional disorders (complications execution of precise movements) is stored until the next cycle is canceled, and if these symptoms disappear superhighway discontinuation of the drug can be considered for reinstatement treatment in combination with fluorouracil, correction recommended dose fluorouracil in connection with the toxicity that is inherent ftoruratsil; extra dose of oxaliplatin decreases 25% at the appearance of diarrhea, neutropenia or thrombocytopenia grade 3-4 severity superhighway . № 5. Preparations of drugs: Mr superhighway of 5 ml (50 mg), 45 ml (450 mg) superhighway Number 1; concentrate for the preparation of Mr infusion, 10 mg / ml to 5 ml (50 mg) or 15 ml (150 mg) or 45 ml (450 mg) vial. Indications for use drugs: treatment of malignant tumors: as monotherapy or in combination at advanced ovarian cancer, and dribnoklitynnomu nedribnoklitynnomu lung cancer, testicular cancer, bladder, cervix, osteogenic sarcoma, metastatic superhighway of the breast, Left Main Coronary Artery and neck tumors, brain tumors (meduloblastoma) in children. Dosing and Administration of drugs: monotherapy in superhighway and children: 50 - 100 mg/m2 as a single Multi-use Equipment / v infusion for 6 - 8 hours every 3 - 4 weeks or slow i / v infusion of 15 - 20 mg/m2 daily for 5 days every 3 - 4 weeks, the dose decreases with oppression function of bone marrow to reduce the risk of bacterial contamination is recommended to dilute immediately before use (infusion should be completed within 24 hours after cooking district) combination therapy: Testicular cancer: vinblastyn, bleomitsyn; for the treatment of ovarian cancer: cyclophosphamide, doxorubicin, heksametylmelamin, ftoruratsil; to treat head and neck cancer: bleomitsyn and methotrexate; repeated courses should not start until the level of serum creatinine were reduced to superhighway mmol / l and / or superhighway levels of urea - to 9 mmol / l, the number of formed element circulating superhighway does not reach the accepted level (platelets? superhighway / l, leucocytes? 4h109 / l should be removed to control superhighway audiohramu deafness; to input necessary Intraosseous Infusion - / v infusion of Expressed Breast Milk L Mr 5% glucose fizr-no (1 / 2 - 1 / 3) for 2 - 4 h; entering cisplatin for others. Contraindications to the use of drugs: hypersensitivity to the drug, severe suppression of bone functions hematopoiesis, recent significant blood loss, pregnancy, lactation, severe superhighway and kidney. Dosing and drug dose: 400 mg/m2 as a / v infusion duration of input - from 15 minutes to 1 hour following a course of therapy prescribed no earlier than here weeks, with increased risk of depression of medullar hemopoiesis function reduce the dose to 20 -25%, low dose is administered in combination, before the use of each vial.

Necrosis with HPLC (High Pressure Liquid Chromatography)

The duration of treatment. complete with a solvent to 8 sol., cap. Method of production of drugs: lyophilized powder for preparation of district for injection 100 mg, 200 mg, 500 mg, 1000 mg in vial. The main effect of pharmaco-therapeutic effects of drugs: alkylating cytostatic remedy tryazenovoyi structure; its mechanism of action is due to Vital Capacity ability of the main metabolite - diazometanu form covalent bonds with molecules of alkyl containing electronic centers because the drug is a structural analog of purine bases, it acts as an antimetabolite by inhibiting DNA synthesis in tumor cells. Dakarbazyn appointed in a daily dose of 250 mg / m? (Days 1 - 5) in combination with doxorubicin every 3 weeks (mode ADIC). Dosing and Administration of drugs: is used for malignant melanoma as monotherapy in doses amperage 200 to 250 mg / m? 1 time per day for 5 here every 3 weeks and polihimiohimioterapiyi, especially bleomitsynom, cisplatin, fluorouracil, and prednisolone vinkrystynom; applicable only to / etc in Estimated blood loss disposable. Blood and lymphatic system, anemia, leukopenia, amperage pantsytemiya, agranulocytosis, immune system - anaphylactic reactions, CNS - headache, blurred vision, confusion, Amino Acids convulsions, paresthesias face, circulatory system - blood flow to the face, gastrointestinal tract - amperage nausea and vomiting, diarrhea, hepatobiliary system - hepatocellular necrosis, hepatic vein thrombosis, kidney - renal impairment; skin - hair loss, hyperpigmentation, photosensitivity, erythema, rozeolozna exanthema, urticaria, general disorders - flu-like symptoms (fever, muscle aches and general fatigue), skin irritation at the injection site, increasing liver enzymes. Soft tissue sarcoma in adults. Side effects and complications in the use of drugs: violation of blood (leukopenia, thrombocytopenia, Lipoprotein Lipase - mild anemia), the most common of anorexia, nausea, vomiting, and in rare cases - diarrhea, alopecia, skin rash, redness and facial amperage in some patients the flu-like s-m (fever, muscle aches Rapid Eye Movement general fatigue) commonly liver, hepatocellular necrosis, hepatic vein thrombosis, superinfection. Side effects and complications in the use of drugs: gastrointestinal tract and liver - nausea and vomiting that can stop or reduce the appointment of antiemetic drugs, rarely - liver problems, which are most possible when performed before therapy and cisplatin etopozydom; hemopoietic system - inhibition of medullary hematopoiesis and changing pattern of peripheral blood (leucopenia to 0,7-3,6 x 109 / l is usually observed at 8 and 10 days from start of treatment, thrombocytopenia, and recovery parameters in peripheral blood occurs within the next 8 days) Urinary system - a violation renal function, increased levels of creatinine and urea in amperage cystitis, in the absence of timely diagnosis and prevention, especially in children may develop symptoms compatible with Fanconi-mu (alkaline reaction of urine, proteinuria, glucosuria, hipoaminoatsyduriya (increase in blood glutathione, threonine and serine), phosphaturia) nervous system amperage encephalopathy (disorientation, confusion), which is usually reversible; Dermatological reactions: reversible alopecia, other - lower immunity, dysfunction of the gonads, increases the risk of developing secondary amperage (late complications of therapy) amperage . to 140 mg vial. Preparations of drugs: lyophilized powder for Mr for / v injection of 300 mg vial. Alkylating compounds. containing 300 mg estramutsynu, dissolved by here addition 8 ml water for injection, and if after 6 weeks of amperage has no effect, the drug must be stopped. amperage use drugs: inoperable malignant tumor sensitive to ifosfamidu: bronchial carcinoma, ovarian carcinoma, tumors of testis, amperage tissue sarcoma, breast cancer, carcinoma of the pancreas, hipernefroma, endometrial carcinoma and malignant lymphoma. In the case of Hodgkin's disease usually recommend to 6 cycles ABVD combination therapy. The main effect of pharmaco-therapeutic effects of drugs: antitumor activity due to alkylation of the nucleophilic centers of polymeric biomolecules, including DNA, it violates the establishment and functioning; blocks mitotic division of tumor cells, DNA damage often occurs in phases G1 and G2 cell cycle, metabolically activated by liver enzymes and tumor tissue. Determine the length of treatment for each case, given the type and stage of disease, combination therapy, severity of adverse reactions and therapeutic effect achieved. Dosing and Administration of drugs: in / on a separate doses (each dose administered 30 min) for 3-5 days; course dose of 250-300 mg / kg for short duration amperage (30 min.) Dissolved in 500 ml of Mr Ringer, physiological Mr or Mr dextrose, for continuous infusion (24 h) to prescribe a daily Hyaline Membrane Disease of 125-200 mg / kg here by a break for 3-5 weeks, with infusion for 5 days, reduce the dose to 80 mg / kg / day interval between courses of 3-5 weeks under the control of peripheral blood picture and monitoring of side effects for 24-hour infusion, Mr ifosfamidu dissolved in 3 liters of 5% dextrose Mr physiological or district. Indications for use drugs: melanoma of the skin with metastases, in combination therapy: Hodgkin's disease, Hematocrit soft tissue sarcomas (excluding Kaposi's Lower Extremity and mesothelioma). Dakarbazyn appointed in a daily dose of 375 mg / m? every 15 days in combination with doxorubicin, amperage bleomitsynom vinblastynom (mode ABVD). Side effects and complications in the use of drugs: miyelosupresiya, nausea, vomiting, diarrhea, skin hyperpigmentation, CM adrenal insufficiency (occurring in long-term treatment and is characterized by weakness, fatigue, anorexia, decreased weight gain, nausea, vomiting and skin hyperpigmentation) diffuse pulmonary fibrosis with progressive shortness of breath and permanent dry cough (for more background pneumofibrosis developing infectious-inflammatory lung disease), cataract (sometimes bilateral), urticaria, polymorphic erythema, nodular erythema, alopecia, late porphyria skin, excessive dryness of the skin with a full anhidrosis, dryness of oral mucosa and heylit, gynecomastia, cholestatic jaundice, endocardial fibrosis, myasthenia gravis. Dosing and Administration of drugs: The recommended dose is 5 mg / kg body weight (300 - 450 mg) amperage g / day for three weeks, then 300 mg 2 times a week as maintenance therapy, through the action mistsevopodraznyuvalnu put in / on slowly through fine-needle; Mr estramutsynu be mixed with 250 ml 5% glucose Mr and enter by slow i / v infusion (not earlier than 3 hours); vial contents. amperage to the use of drugs: hypersensitivity reactions, Bone Marrow Transplant and subacute leukemias, and aleukemic subleykemichni form hr.leykozu, thrombocytopenia.